Clinical study evaluating β-blockers use and fracture risk in patients with primary osteoporosis Running title

Background and objectives: In osteoporosis, low bone mass growing fragility are main symptoms. BB users had greater BMD and/or decreased fracture risk, according to observational studies. Other studies found no effect of on risk osteoporosis disease. this study, the selective non-selective in osteoporotic individuals was studied. Methods: A total fifty patients both genders were included randomized controlled, parallel, prospective trial. Osteoporotic subjects divided into three groups: a control group (CG), beta-blocker (NSBB), cardio-selective (CSBB). T-score, (FR), mineral density (BMD), turnover markers studied as result investigation. Results: After six months follow-up, it discovered that T-score mean values groups varied significantly. significantly higher receiving beta-blockers (NSBB) than (CG). categories region, statistically NSBB CSBB groups. Additionally, demonstrated decrease (BTM), contrasted group.